Genetics and Epigenetics in Neurological Disorders

Genetics and epigenetics play crucial roles in neurological disorders such as dementia and Alzheimer’s. Genetic mutations, including those in the APP, PSEN1, and PSEN2 genes, are linked to early-onset Alzheimer's, while APOE4 variant influences late-onset risk. Epigenetic modifications, such as DNA methylation and histone modification, can alter gene expression without changing the DNA sequence, impacting disease progression. These changes might be reversible and offer potential therapeutic targets. Translational research is advancing our understanding of these mechanisms, aiming to develop personalized treatments and preventive strategies. Future directions involve leveraging genomic and epigenomic insights to innovate novel interventions for neurological disorders.

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