Zhejiang University School of Medicine, China
Title: Using ASL technology to observe the regulating effect of CBF on memory in ApoE Genotype：The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Biography: Junyang Wang
Background/Aims: To use cerebral blood flow (CBF) measurements with the arterial spin labeling (ASL) technique to assess difference between ApoEε4 gene carriers and noncarriers and to observe the regulating effect of CBF on memory functions.
Methods：A total of 62 healthy elderly subjects without subjective memory impairment and with normal score of Mini–Mental State Examination (MMSE) were drawn from the Alzheimer’s disease Neuroimaging Initiative (ADNI) database; of whom 23 were ApoEε4 gene carriers and 39 were no carriers. The following three Regions of Interest (ROI) were selected for CBF measurements: medial temporal lobe (hippocampus, Para hippocampal gyrus and uncus), inferior parietal lobe (supramarginal gyrus，inferior parietal lobule and angular gyrus), and frontal cortex (anterior cingulate gyrus, middle frontal gyrus and medial frontal gyrus). At the same time, the Rey Auditory Verbal Learning Test (RAVLT) was performed on all subjects to test their verbal memory function, and the results were correlated with the CBF.
Results: The CBF in the ROIs was positively correlated with verbal memory function in the non-carriers. By contrast, in ApoEε4 carriers the CBF value from the ROIs was negatively correlated to verbal memory function.
Conclusion: For ApoEε4 carriers, an increased CBF does not compensate for memory function loss. That is to say, the regulating effect of CBF is affected in ApoEε4 carriers.