Shima Ebrahimi khonacha
Shahid Beheshti University of Medical Sciences, Iran
Title: The protective role of Kisspeptin in learning and memory impairment due to injection of intra- hippocampal amyloid beta in rats
Biography
Biography: Shima Ebrahimi khonacha
Abstract
It has been shown that brain glucose metabolism impairment, obesity and diabetes could lead to cognitive decline and Alzheimer’s disease (AD) pathogenesis. Kisspeptin (KP) a G-protein coupled receptor neuropeptide has been suggested as a link between energy balance and reproduction. Some studies have shown that attenuation of KP signaling decreases metabolism and energy expenditure. KP is detected in the hippocampus and causes promotion of excitatory synaptic responses through modulation of postsynaptic signaling. The purpose of this study was to investigate the possible protective role of kisspeptin on cognitive function in rat model of AD using Morris Water Maze (MWM) task. Reference spatial learning and memory and reverse spatial learning and memory have been measured in this study. Rats were injected bilaterally by Aβ1-42 (MWM) or saline as vehicle into the hippocampal CA1. One week later, Kisspeptin13 (0.75 or 1 µg/µl) or saline as vehicle were injected intra cerebroventricularly before each training session for 3 days. The results of our investigation showed Aβ could not disrupt reference spatial learning but impaired significantly spatial reference memory, by increasing escape latency and decreasing time spent in the target zone. This impairment was reduced by KP in both doses. In another part of this study spatial reverse learning and memory was performed by changing the platform position. Aβ injection impaired both reverse learning and memory in MWM task. The Learning and memory deficits were significantly reversed by KP injections.
In Conclusion, it seems that KP as a neuropeptide could be a candidate for improving memory deficits resulting from Aβ toxicity in which needs to be further investigated.